Pointpusher Danny Williams with this little tutorial covers how to adjust the Zbrush 4.0 UI. These steps also work for previous versions of Zbrush. Feel free to download the custom UI here: pointpusher.com/prefs/zBrush/4.0/ZStartup.zip
Mini-tutorial: Zbrush 4.0 custom UI from pointpusher on Vimeo.
I use a similar custom brush palette, but I find that 90% of the time I’m only using 3-5 brushes when sculpting (std, move, pinch, etc) – so on top of that I just assign hotkeys to those brushes; that way you aren’t constantly stopping and and starting. You can also assign the bracket keys for your brush size in the zplugin>misc utilities menu. This way you don’t have to constantly stop and/or right click to change the brush draw size. The above combined with the ‘tab’ key to enter into expert mode give a nice and clean interface.
Most tutorials of this nature are done by less-than-fantastic artists. You know… the more… technical types. So it’s awesome to get a technical oriented tut by a guy who is also a blazingly kick-ass artist!