Iridesium explains how you can create a simple but massive explosion in Blender using Manatflow.

Joel Adams (Iridesium) posts a tutorial that shows how you can get started with Mantaflow in Blender to create a fantastic looking massive explosion. The tutorial covers some of the good and bad of Mantaflow. The video is a great starter that dives into what is involved with building a blast like this.

Mantaflow in Blender.

Mantaflow handles gas, smoke, fire, and liquid simulations, and replaces the existing fluid simulation systems in Blender completely. Mantaflow comes from an open-source fluid simulation framework developed and maintained at the Games Engineering group of the Technical University of Munich (TUM).

Other Mantaflow tutorials to get you going.

• Resilient Picture Company shows how you can make a realistic explosion using Houdini, Blender, and Natron. 
• CG Geek shows how to create water and splashes using Blender’s Mantaflow.
• Sardi Pax has a quick look at using MantaFlow smoke and fire in Blender. 
• The Blender Made Easy Channel (hosted by Stephen Pearson) shows us how to create a fire sim using this new simulator.