New Plastic shows how to make incredibly realistic skin with C4D and Octane Render.
A new tutorial from the New Plastic channel shows how you can build hyper-realistic skin in Cinema 4D using Octane. The tutorial covers two methods for creating a skin surface: a mixed materials approach and the other using only a single material.
Each rendering engine has its shader for dealing with skin. Check out this rendering tutorial from Morgraph+ shows an approach to create realistic skin shaders with Arnold in Maxon Cinema 4D, using some readily available assets. Also, be sure to check out this excerpt from MographPlus that shows how to create super-realistic skin using Corona Render in C4D.